Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC006
Test date and time 2022-02-18 06:21
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment cMadopar tba a 250mg 3x1/4 Madopar HBS caps a 125mg 1 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 41 individuals with a value less than 0.75 were subsequently diagnosed with PD. That is, 97.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.75 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 20, 'TN': 10, 'TP': 22, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 11, 'TN': 8, 'TP': 31, 'FP': 22}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4.036
timePerCircleCoV 0.613126
timePerCircleSlope 0.0815088
meanError 3.794
tremorFreq 5.95703
tremorRelPower 30.0967
tremorGyroAmpMean 0.0291519
tremorGyroAmpSlope -0.00992529
tremorGyroAmpCoV 0.266178
tremorCoordAmpMean 0.0615875
tremorCoordAmpSlope 0.00679578
tremorCoordAmpCoV 0.293562
tremorAccAmpMean 0.0387032
tremorAccAmpSlope -0.00341471
tremorAccAmpCoV 0.27789
tremorPcRelVar 0.654733
tremorPcX -0.473837
tremorPcY 0.880613

Circle Segment 1

Duration 4.48 s, Accuracy Estimate 3.69 (lower is better)

Circle Segment 2

Duration 3.72 s, Accuracy Estimate 4.667 (lower is better)

Circle Segment 3

Duration 3.32 s, Accuracy Estimate 3.662 (lower is better)

Circle Segment 4

Duration 2.76 s, Accuracy Estimate 3.85 (lower is better)

Circle Segment 5

Duration 3.04 s, Accuracy Estimate 3.672 (lower is better)

Circle Segment 6

Duration 2.8 s, Accuracy Estimate 3.129 (lower is better)

Circle Segment 7

Duration 3.0 s, Accuracy Estimate 2.988 (lower is better)

Circle Segment 8

Duration 2.88 s, Accuracy Estimate 4.269 (lower is better)

Circle Segment 9

Duration 3.44 s, Accuracy Estimate 4.034 (lower is better)

Circle Segment 10

Duration 10.92 s, Accuracy Estimate 3.98 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 17.988
timePerSpiralCoV 0.113223
timePerSpiralSlope 0.00820749
meanError 2.47319
tremorFreq 5.56641
tremorRelPower 26.1985
tremorGyroAmpMean 0.0298182
tremorGyroAmpSlope 0.00190289
tremorGyroAmpCoV 0.372082
tremorCoordAmpMean 0.0527231
tremorCoordAmpSlope 0.00151352
tremorCoordAmpCoV 0.320202
tremorAccAmpMean 0.0577582
tremorAccAmpSlope 0.000825695
tremorAccAmpCoV 0.177019
tremorPcRelVar 0.63659
tremorPcX -0.484281
tremorPcY -0.874913

Spiral Segment 1

Duration 16.44 s, Accuracy Estimate 2.33 (lower is better)

Spiral Segment 2

Duration 21.0 s, Accuracy Estimate 2.285 (lower is better)

Spiral Segment 3

Duration 16.4 s, Accuracy Estimate 2.295 (lower is better)

Spiral Segment 4

Duration 16.32 s, Accuracy Estimate 2.407 (lower is better)

Spiral Segment 5

Duration 17.04 s, Accuracy Estimate 1.87 (lower is better)

Spiral Segment 6

Duration 19.64 s, Accuracy Estimate 2.737 (lower is better)

Spiral Segment 7

Duration 18.16 s, Accuracy Estimate 2.42 (lower is better)

Spiral Segment 8

Duration 15.0 s, Accuracy Estimate 2.694 (lower is better)

Spiral Segment 9

Duration 20.36 s, Accuracy Estimate 3.23 (lower is better)

Spiral Segment 10

Duration 19.52 s, Accuracy Estimate 2.464 (lower is better)

Elel

eDurationMean 0.408175
eDurationStd 0.0864768
eDurationStdnorm 0.211862
eDurationMedian 0.390011
eDurationQuartdelta 0.106253
eDurationQuartdeltanorm 0.272436
eDurationKurt 3.75076
eDurationTrenddiff -0.0550016
eDurationTrendratio 0.869048
eWidthMean 3.66054
eWidthStd 2.42124
eWidthStdnorm 0.661444
eWidthMedian 3.159
eWidthQuartdelta 2.58495
eWidthQuartdeltanorm 0.818281
eWidthKurt 6.8901
eWidthTrenddiff -0.698149
eWidthTrendratio 0.801908
eHeightMean 8.9276
eHeightStd 3.92575
eHeightStdnorm 0.439732
eHeightMedian 7.90683
eHeightQuartdelta 2.53897
eHeightQuartdeltanorm 0.321111
eHeightKurt 7.90165
eHeightTrenddiff -1.80732
eHeightTrendratio 0.804336
eAspectMean 0.404893
eAspectStd 0.193525
eAspectStdnorm 0.477964
eAspectMedian 0.376623
eAspectQuartdelta 0.213616
eAspectQuartdeltanorm 0.567188
eAspectKurt 4.50729
eAspectTrenddiff -0.0339026
eAspectTrendratio 0.916696
eSlantMean -0.078071
eSlantStd 0.272879
eSlantStdnorm -3.49527
eSlantMedian -0.0499078
eSlantQuartdelta 0.402778
eSlantQuartdeltanorm -8.07044
eSlantKurt 2.8532
eSlantTrenddiff -0.103586
eRtopMean 0.730758
eRtopStd 0.182586
eRtopStdnorm 0.249858
eRtopMedian 0.769457
eRtopQuartdelta 0.205479
eRtopQuartdeltanorm 0.267044
eRtopKurt 3.19597
eRtopTrenddiff -0.129651
eRbotMean 1.26294
eRbotStd 1.0376
eRbotStdnorm 0.821571
eRbotMedian 0.826124
eRbotQuartdelta 1.29426
eRbotQuartdeltanorm 1.56667
eRbotKurt 4.84115
eRbotTrenddiff 0.0924626
eRrightMean 0.875479
eRrightStd 0.0937332
eRrightStdnorm 0.107065
eRrightMedian 0.890085
eRrightQuartdelta 0.0980223
eRrightQuartdeltanorm 0.110127
eRrightKurt 5.50447
eRrightTrenddiff -0.0414413
eRleftMean 0.487884
eRleftStd 0.170081
eRleftStdnorm 0.348608
eRleftMedian 0.506742
eRleftQuartdelta 0.205684
eRleftQuartdeltanorm 0.405894
eRleftKurt 2.51344
eRleftTrenddiff 0.0793515
lDurationMean 0.524525
lDurationStd 0.113754
lDurationStdnorm 0.216871
lDurationMedian 0.510015
lDurationQuartdelta 0.133754
lDurationQuartdeltanorm 0.262255
lDurationKurt 3.20734
lDurationTrenddiff -0.130004
lDurationTrendratio 0.77193
lWidthMean 7.45334
lWidthStd 3.96282
lWidthStdnorm 0.531684
lWidthMedian 7.02
lWidthQuartdelta 5.17628
lWidthQuartdeltanorm 0.737361
lWidthKurt 2.62484
lWidthTrenddiff -5.25196
lWidthTrendratio 0.451834
lHeightMean 21.1893
lHeightStd 6.08723
lHeightStdnorm 0.287279
lHeightMedian 20.007
lHeightQuartdelta 5.42068
lHeightQuartdeltanorm 0.270939
lHeightKurt 3.58854
lHeightTrenddiff -4.8347
lHeightTrendratio 0.786252
lAspectMean 0.337214
lAspectStd 0.115692
lAspectStdnorm 0.343081
lAspectMedian 0.322468
lAspectQuartdelta 0.182985
lAspectQuartdeltanorm 0.567452
lAspectKurt 2.49486
lAspectTrenddiff -0.172471
lAspectTrendratio 0.591757
lSlantMean 0.0763272
lSlantStd 0.158943
lSlantStdnorm 2.08239
lSlantMedian 0.112939
lSlantQuartdelta 0.242613
lSlantQuartdeltanorm 2.14817
lSlantKurt 2.21088
lSlantTrenddiff -0.241838
lRtopMean 0.871033
lRtopStd 0.0986794
lRtopStdnorm 0.11329
lRtopMedian 0.902012
lRtopQuartdelta 0.126465
lRtopQuartdeltanorm 0.140203
lRtopKurt 3.79291
lRtopTrenddiff -0.0136131
lRbotMean 0.805637
lRbotStd 0.660398
lRbotStdnorm 0.819721
lRbotMedian 0.542881
lRbotQuartdelta 0.674054
lRbotQuartdeltanorm 1.24162
lRbotKurt 11.2969
lRbotTrenddiff 0.669579
lRrightMean 0.928587
lRrightStd 0.0709971
lRrightStdnorm 0.0764572
lRrightMedian 0.95381
lRrightQuartdelta 0.0523347
lRrightQuartdeltanorm 0.054869
lRrightKurt 9.31514
lRrightTrenddiff 0.00162605
lRleftMean 0.299385
lRleftStd 0.143744
lRleftStdnorm 0.480132
lRleftMedian 0.262225
lRleftQuartdelta 0.187759
lRleftQuartdeltanorm 0.71602
lRleftKurt 2.82545
lRleftTrenddiff 0.182303

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.716563
sumTouchScores 7.16563
meanMovementTime 1.265
numTouches 10
undershootPercentage 0
overshootPercentage 40

FITTS Long Modified

meanTouchScore 0.713911
sumTouchScores 6.4252
meanMovementTime 1.37187
numTouches 9
undershootPercentage 0
overshootPercentage 22.2222

ZigZag

numZigzags 5
timePerZigzagMean 22
timePerZigzagCoV 0.0798863
timePerZigzagSlope 0.0358182
meanError 2.36676
tremorFreq 5.56641
tremorRelPower 21.3859
tremorGyroAmpMean 0.0388937
tremorGyroAmpSlope -0.00361099
tremorGyroAmpCoV 0.393576
tremorCoordAmpMean 0.0641403
tremorCoordAmpSlope -0.00236002
tremorCoordAmpCoV 0.22654
tremorAccAmpMean 0.0732528
tremorAccAmpSlope -0.00299114
tremorAccAmpCoV 0.256415
tremorPcRelVar 0.615862
tremorPcX 0.445998
tremorPcY -0.895034

ZigZag Segment 1

Duration 18.96 s, Accuracy Estimate 2.867 (lower is better)

ZigZag Segment 2

Duration 22.32 s, Accuracy Estimate 2.631 (lower is better)

ZigZag Segment 3

Duration 22.96 s, Accuracy Estimate 2.083 (lower is better)

ZigZag Segment 4

Duration 23.4 s, Accuracy Estimate 2.086 (lower is better)

ZigZag Segment 5

Duration 22.36 s, Accuracy Estimate 2.167 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 20.472
timePerZigzagCoV 0.180708
timePerZigzagSlope -0.0959359
zigzagHeightMean 63.4092
zigzagHeightCoV 0.0786444
zigzagHeightSlope -0.0185486
meanError 0.0644297
tremorFreq 5.37109
tremorRelPower 24.0633
tremorGyroAmpMean 0.0425795
tremorGyroAmpSlope -0.00166695
tremorGyroAmpCoV 0.438523
tremorCoordAmpMean 0.143911
tremorCoordAmpSlope -0.012865
tremorCoordAmpCoV 2.6571
tremorAccAmpMean 0.0646918
tremorAccAmpSlope -0.00276007
tremorAccAmpCoV 0.466684
tremorPcRelVar 0.937141
tremorPcX 0.791207
tremorPcY 0.611548

ZigZag Offset Segment 1

Duration 26.56 s, Accuracy Estimate 0.106 (lower is better)

ZigZag Offset Segment 2

Duration 19.32 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 3

Duration 21.16 s, Accuracy Estimate 0.111 (lower is better)

ZigZag Offset Segment 4

Duration 17.84 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 17.48 s, Accuracy Estimate 0.046 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.57}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.75}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.917207613508555}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8004174270961628}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7978055543766501}